Investigation of acute toxicity of Malathion and Cypermethrin on Clinico-hematological parameters in female New Zealand White Rabbits (Oryctolagus cuniculus)

The aim of the present study was to find the clinical and hematological alterations in female rabbits exposed orally to Malathion and Cypermethrin at a dose of 75mg/kg body weight for seven days through gavage. Animals were divided into three groups i.e. A, B and C comprised of three rabbits each. Group A was considered as control. Group B was intoxicated with Malathion while C was Cypermethrin intoxicated group. All the animals were monitored twice a day for clinical signs. Signs like grinding of teeth, salivation, licking of legs, incoordination, dizziness, increased urinations, and jerky movements persisted for 30 to 90 minutes after intoxication. Malathion intoxication exhibited significant decrease in MCH and PLT and showed decrease in WBCs and MCHC levels. It also produced increase in RBCs, PCV and MCV levels. Cypermethrin administration produced increase in WBCs, RBCs, PCV, MCH, PLT and significant increase in MCHC. It is concluded from the present results that both the insecticides were neurotoxic in nature and have leukopenic and leukemic tendency for female rabbits